Skin whitening cosmetics are one of the most demanded products in Asia and other continents. It is known that skin color is affected by melanin synthesis, which is produced in melanocytes in the basal layer of human epidermis. Melanin has various important physiological function such as been the major defense mechanism against visible and ultraviolet radiation.
Due to the impossibility to use animals for cosmetic experimentation, many researchers are looking for new alternatives. The zebrafish model appears as an option for replacing superior animal experiments.
In the last few years, some publications have appeared supporting the use of Danio rerio as a model to evaluate whitening effect have appeared.