Immunotox Assay

Zebrafish is a unique model for pharmacological manipulation of the innate and adaptive immune response. They are small and permeable to many small compounds and there are several transgenic lines available to visualize immune cells.

Taking advantage of zebrafish embryo transparency, we can test the toxicity of pharmacological, agrochemical and cosmetic compounds to the innate and adaptive immune system by quantifying these cell populations. Additionally, this model can also be used to identify new anti-inflammatory compounds, by following leukocyte recruitment to inflammation induced by sterile tissue injury.

Biobide has developed an assay in zebrafish embryos to detect compounds with specific toxicity for the immune system and to screen and identify new anti-inflammatory drugs.