Helmholtz Centre’s for Environmental Research publication in Toxicological Sciences Journal: a collaborative work with Biobide and Sanofi

It’s the second co-authored Biobide’s article that was published this month and this time it’s in Oxford Academic’s Toxicological Sciences Journal. Although research has been mainly developed by the scientists of the Helmholtz Centre for Environmental Research, some of the experiments described were performed in Biobide and Sanofi.

The main goal of this investigation was to create a new, automated and more objective method for screening developmental toxicity in zebrafish embryos. Currently, developmental toxicity is evaluated via a visual inspection and although scientists, carrying out the analysis are fully qualified to objectively evaluate the embryos, a certain level of subjectivity and variability between investigators’ criteria still remain.

During the collaboration, investigators developed a software named FishInspector, destined to detect morphological features from images collected using an automated system to position embryos. Analysis was compared with visual evaluations from all three laboratories and improved the sensitivity, robustness and reliability of this approach which can be used to improve the predictivity of developmental toxicity screening in zebrafish.

To access Helmholtz Centre’s for Environmental Research, Biobide’s, and Sanofi’s article please click here.

To obtain further information about our contribution to this investigation or our zebrafish assay pipeline, please contact us via our website.