Dr. MacRae trained in Internal Medicine and Cardiology in Edinburgh and London before moving to the Department of Genetics at Harvard Medical School in 1991 for postdoctoral work. After additional clinical training, he joined the faculty at the Massachusetts General Hospital in 2000 where he was Cardiovascular Medicine Training Program Director until he returned to Brigham and Women’s Hospital in 2009. He became the Chief of Cardiovascular Medicine at Brigham and Women’s Hospital in 2014 and is also an Associate Member of the Broad Institute of Harvard and MIT and a Principal Faculty Member in the Harvard Stem Cell Institute.
Dr. MacRae’s scientific work spans human genetics, cardiovascular developmental biology and drug discovery. His group has used the zebrafish as a tool for high-throughput approaches to genome annotation and understanding disease biology. His laboratory is currently integrating clinical genomics with animal modeling to accelerate therapeutic innovation. Dr. MacRae’s major clinical focus is inherited heart disease. He leads an Innovation program to use genomics, electronic records, digital technologies and learning medical systems in the stratification and management of common disease.